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I found this: https://www.insanelymac.com/forum/topic/329390-amd-firepro-w5100-on-macpro-51-high-sierra/ Seems that the card will work with these mods, you will just have a blank boot screen until the system starts. I'm planning to change my FirePro W5100 with a Quadro M1200 because I need CUDA for what I'm working on.1 point