SSDT GPI0 is NOT needed anymore with the latest I2C kext, features have been improved, but in this case it is essential to use SSDT-XOSI or a FIX SSDT-I2C0 TPD0 with specific Darwin according to ACPI Origin example as in the attached photo. This would be the TOP with Opencore bootloader
in this case we avoid rename in config that Opencore DOESN'T like
As for the brightness keys, let the new BrightnessKeys do its job , good hackintosh
Try to replace this SSDT restart, and post ioreg, let's see if the touchscreen activates
SSDT-Dell Inspiron 5378.aml.zip