Dear clif,
There are a few ways of doing it. It is the easiest if you can make your new hard disk into an external hard disk for transfer purpose.
Once you have that, you need to create two new partition say 80 gig each on you new hard disk, use disk utility from your installer usb to create an image of the old hard disk to the second partition and restoring it to the first partition of your new hard drive. You can then boot into your new hard disk to test it, delete the second partition and expand your first partition to use the entire new disk. Lastly, install chemeleon to the new hard disk.
Well, that's one way of doing it especially if you don't have a second os system and just the usb installer.
Cheers!