You should have no issue upgrading to 10.10.5 with combo update. Make sure to add nullcpupowermanagement to /extra/extensions prior to the update as stated in my guide. Then install the updated files and then remove NullCPU...
If you want to stick with Chameleon loader when installing El Capitan, this is a good guide, just use your current /Extra folder as bootpack.
Only significant change is that you need the Enoch branch of Chameleon and SIP disabled, all covered in Hervé's guide.
Otherwise, I have a Clover guide for El Capitan, use the E6420 bootpack but replace DSDT with your current DSDT.